NaHS or Lovastatin Attenuates Cyclosporine A–Induced Hypertension in Rats by Inhibiting Epithelial Sodium Channels

The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects of causing severe hypertension. We have previously shown that CsA increases the activity of the epithelial sodium channel (ENaC) in cultured distal nephron cells. However, it remains unknown whether ENaC medi...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Qiu-Shi, Liang, Chen, Jiang, Shuai, Zhu, Di, Sun, Yu, Niu, Na, Yang, Xu, Yang, Yan-Chao, Dong, Bi-Han, Yao, Jie, Yu, Chang-Jiang, Lou, Jie, Tang, Liang-Liang, Wu, Ming-Ming, Zhang, Zhi-Ren, Ma, He-Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187945/
https://ncbi.nlm.nih.gov/pubmed/34122084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.665111
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