NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the NOTCH1 and IGHV Mutational Status

NOTCH1 mutations and deregulated signal have been commonly found in chronic lymphocytic leukemia (CLL) patients. Whereas the impact of NOTCH1 mutations on clinical course of CLL has been widely studied, the prognostic role of NOTCH1 activation in CLL remains to be defined. Here, we analyzed the acti...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Oncol
Auteurs principaux: Baldoni, Stefano, Del Papa, Beatrice, De Falco, Filomena, Dorillo, Erica, Sorrentino, Carlo, Rompietti, Chiara, Adamo, Francesco Maria, Nogarotto, Manuel, Cecchini, Debora, Mondani, Elena, Silva Barcelos, Estevao Carlos, Moretti, Lorenzo, Mameli, Maria Grazia, Fabi, Bianca, Sorcini, Daniele, Stella, Arianna, Giancola, Raffaella, Guardalupi, Francesco, Ulbar, Francesca, Plebani, Sara, Guarente, Valerio, Rosati, Emanuela, Di Nicola, Marta, Marchioni, Michele, Di Ianni, Mauro, Sportoletti, Paolo
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187905/
https://ncbi.nlm.nih.gov/pubmed/34123837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.668573
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