Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α

Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity in patients and drug resistance. So, we implemented a therapeutic...

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Udgivet i:Front Oncol
Main Authors: Coronel-Hernández, Jossimar, Salgado-García, Rebeca, Cantú-De León, David, Jacobo-Herrera, Nadia, Millan-Catalan, Oliver, Delgado-Waldo, Izamary, Campos-Parra, Alma D., Rodríguez-Morales, Miguel, Delgado-Buenrostro, Norma L., Pérez-Plasencia, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187873/
https://ncbi.nlm.nih.gov/pubmed/34123772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.594200
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