Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system

Prolonged hyperglycemia plays a major role in the progression of β-cell loss in diabetes mellitus. Here we report an insulin sensitizer thiazolidinedione Pioglitazone selectively preserves the beta cells against high glucose-induced dysfunction by activation of AMPK and Glutaminase 1 (GLS1) axis. AM...

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Vydáno v:Redox Biol
Hlavní autoři: Karunakaran, Udayakumar, Elumalai, Suma, Moon, Jun Sung, Won, Kyu Chang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187239/
https://ncbi.nlm.nih.gov/pubmed/34107382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102029
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