Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells

We recently reported that cluster determinant 36 (CD36), a fatty acid transporter, plays a pivotal role in glucotoxicity-induced β-cell dysfunction. However, little is known about how glucotoxicity influences CD36 expression. Emerging evidence suggests that the small GTPase Rac1 is involved in the p...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Elumalai, Suma, Karunakaran, Udayakumar, Lee, In Kyu, Moon, Jun Sung, Won, Kyu Chang
Format: Artigo
Language:Inglês
Published: Elsevier 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133656/
https://ncbi.nlm.nih.gov/pubmed/27912197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.11.009
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