Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu)

BACKGROUND: Local ischemia and defective osteogenesis are implicated in the progression of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies have revealed that exosomes released from adipose-derived stem cells (ASCs) play important roles in ONFH therapy. The presen...

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Udgivet i:Stem Cell Res Ther
Main Authors: Nan, Kai, Zhang, Yuankai, Zhang, Xin, Li, Dong, Zhao, Yan, Jing, Zhaopu, Liu, Kang, Shang, Donglong, Geng, Zilong, Fan, Lihong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186190/
https://ncbi.nlm.nih.gov/pubmed/34099038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02390-x
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