Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain

Activated ezrin-radixin-moesin (ERM) proteins link the plasma membrane to the actin cytoskeleton to generate apical structures, including microvilli. Among many kinases implicated in ERM activation are the homologues LOK and SLK. CRISPR/Cas9 was used to knock out all ERM proteins or LOK/SLK in human...

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Vydáno v:J Cell Biol
Hlavní autoři: Zaman, Riasat, Lombardo, Andrew, Sauvanet, Cécile, Viswanatha, Raghuvir, Awad, Valerie, Bonomo, Locke Ezra-Ros, McDermitt, David, Bretscher, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185690/
https://ncbi.nlm.nih.gov/pubmed/33836044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007146
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