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Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain
Activated ezrin-radixin-moesin (ERM) proteins link the plasma membrane to the actin cytoskeleton to generate apical structures, including microvilli. Among many kinases implicated in ERM activation are the homologues LOK and SLK. CRISPR/Cas9 was used to knock out all ERM proteins or LOK/SLK in human...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8185690/ https://ncbi.nlm.nih.gov/pubmed/33836044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007146 |
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