Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied donor weight loss. Furthermore, muscle wasting correlated with mortality and murine IL-6, and human IL-6 associated with the grea...

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Rupert, Joseph E., Narasimhan, Ashok, Jengelley, Daenique H.A., Jiang, Yanlin, Liu, Jianguo, Au, Ernie, Silverman, Libbie M., Sandusky, George, Bonetto, Andrea, Cao, Sha, Lu, Xiaoyu, O’Connell, Thomas M., Liu, Yunlong, Koniaris, Leonidas G., Zimmers, Teresa A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2021
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185651/
https://ncbi.nlm.nih.gov/pubmed/33851955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190450
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