Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for TIL. To investigate this possibility, we used a MMTV‐...

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Pubblicato in:EMBO Mol Med
Autori principali: Murdamoothoo, Devadarssen, Sun, Zhen, Yilmaz, Alev, Riegel, Gilles, Abou‐Faycal, Chérine, Deligne, Claire, Velazquez‐Quesada, Ines, Erne, William, Nascimento, Marine, Mörgelin, Matthias, Cremel, Gérard, Paul, Nicodème, Carapito, Raphael, Veber, Romain, Dumortier, Hélène, Yuan, Jingping, Midwood, Kim S, Loustau, Thomas, Orend, Gertraud
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185552/
https://ncbi.nlm.nih.gov/pubmed/33988305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202013270
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