Gastruloids generated without exogenous Wnt activation develop anterior neural tissues

When stimulated with a pulse from an exogenous WNT pathway activator, small aggregates of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and patterning along the three major body axes. However, these structures, called gastruloids, currently lack the anterior embryonic...

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Udgivet i:Stem Cell Reports
Main Authors: Girgin, Mehmet U., Broguiere, Nicolas, Mattolini, Lorenzo, Lutolf, Matthias P.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185432/
https://ncbi.nlm.nih.gov/pubmed/33891872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.03.017
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