Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein we found that myeloid-specific knockout of Kdm2a (LysM-Cre-Kdm2a(f/f), Kdm2a(−/−)) promoted macrophage M2 program by reprograming metabolic homeostasi...

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書誌詳細
出版年:Cell Death Differ
主要な著者: Chen, Longmin, Zhang, Jing, Zou, Yuan, Wang, Faxi, Li, Jingyi, Sun, Fei, Luo, Xi, Zhang, Meng, Guo, Yanchao, Yu, Qilin, Yang, Ping, Zhou, Qing, Chen, Zhishui, Zhang, Huilan, Gong, Quan, Zhao, Jiajun, Eizirik, Decio L., Zhou, Zhiguang, Xiong, Fei, Zhang, Shu, Wang, Cong-Yi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185071/
https://ncbi.nlm.nih.gov/pubmed/33462408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00714-7
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