Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein we found that myeloid-specific knockout of Kdm2a (LysM-Cre-Kdm2a(f/f), Kdm2a(−/−)) promoted macrophage M2 program by reprograming metabolic homeostasi...

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Udgivet i:Cell Death Differ
Main Authors: Chen, Longmin, Zhang, Jing, Zou, Yuan, Wang, Faxi, Li, Jingyi, Sun, Fei, Luo, Xi, Zhang, Meng, Guo, Yanchao, Yu, Qilin, Yang, Ping, Zhou, Qing, Chen, Zhishui, Zhang, Huilan, Gong, Quan, Zhao, Jiajun, Eizirik, Decio L., Zhou, Zhiguang, Xiong, Fei, Zhang, Shu, Wang, Cong-Yi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185071/
https://ncbi.nlm.nih.gov/pubmed/33462408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00714-7
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