Preclinical immunogenicity testing using anti-drug antibody analysis of GX-G3, Fc-fused recombinant human granulocyte colony-stimulating factor, in rat and monkey models

Human granulocyte colony-stimulating factor (G-CSF, this study used Fc-fused recombinant G-CSF; GX-G3) is an important glycoprotein that stimulates the proliferation of granulocytes and white blood cells. Thus, G-CSF treatment has been considered as a crucial regimen to accelerate recovery from chem...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kim, Yun Jung, Koh, Eun Mi, Song, Chi Hun, Byun, Mi Sun, Choi, Yu Ri, Jeon, Eun-Jeong, Hwang, Kyunghwa, Kim, Sang Kyum, Yang, Sang In, Jung, Kyung Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184775/
https://ncbi.nlm.nih.gov/pubmed/34099775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91360-7
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