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Changes in Sialic Acid Binding Associated with Egg Adaptation Decrease Live Attenuated Influenza Virus Replication in Human Nasal Epithelial Cell Cultures
Live Attenuated Influenza Virus (LAIV) is administered to and replicates in the sinonasal epithelium. Candidate LAIV vaccine strains are selected based on their ability to replicate to a high titer in embryonated hen’s eggs, a process that can lead to mutations which alter the receptor binding and a...
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| Wydane w: | Vaccine |
|---|---|
| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8184632/ https://ncbi.nlm.nih.gov/pubmed/33985852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2021.04.057 |
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