Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca(2+) and phosphorylation

Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca(2+)-transport response to β-adrenergic stimulation, thus modulating cardiac output during the fight-or-flight response. In the sarcoplasmic reticulum membrane, PLN binds to the sarco(endo)plasmic reticulum Ca(2+)-AT...

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Опубликовано в: :eLife
Главные авторы: Weber, Daniel K, Reddy, U Venkateswara, Wang, Songlin, Larsen, Erik K, Gopinath, Tata, Gustavsson, Martin B, Cornea, Razvan L, Thomas, David D, De Simone, Alfonso, Veglia, Gianluigi
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2021
Предметы:
Structural Biology and Molecular Biophysics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184213/
https://ncbi.nlm.nih.gov/pubmed/33978571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66226
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