Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

Genomes of tumors that are deficient in DNA mismatch repair (dMMR) have high microsatellite instability (MSI-H) and harbor hundreds to thousands of somatic mutations that encode potential neoantigens. Such tumors are therefore likely to be immunogenic, triggering upregulation of immune checkpoint pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Clin Oncol
Hauptverfasser: Marabelle, Aurelien, Le, Dung T., Ascierto, Paolo A., Di Giacomo, Anna Maria, De Jesus-Acosta, Ana, Delord, Jean-Pierre, Geva, Ravit, Gottfried, Maya, Penel, Nicolas, Hansen, Aaron R., Piha-Paul, Sarina A., Doi, Toshihiko, Gao, Bo, Chung, Hyun Cheol, Lopez-Martin, Jose, Bang, Yung-Jue, Frommer, Ronnie Shapira, Shah, Manisha, Ghori, Razi, Joe, Andrew K., Pruitt, Scott K., Diaz Jr, Luis A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2020
Schlagworte:
Rapid Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184060/
https://ncbi.nlm.nih.gov/pubmed/31682550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.02105
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge