Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1(157-165) tumor-specific peptide

BACKGROUND: NY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development. The mouse genome does not encode an NY-ESO-1 homolog thereby not subjecting transgenic T-cells to thymic to...

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Publicado en:J Immunother Cancer
Autores principales: Shenderov, Eugene, Kandasamy, Matheswaran, Gileadi, Uzi, Chen, Jili, Shepherd, Dawn, Gibbs, James, Prota, Gennaro, Silk, Jonathan D, Yewdell, Jonathan W, Cerundolo, Vincenzo
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183295/
https://ncbi.nlm.nih.gov/pubmed/34088742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002544
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