Chronic Dietary Branched-Chain Amino Acids Induced Lipid Oxidation and Blunted Insulin-Stimulated Glucose Production in Mice With NAFLD

OBJECTIVES: Elevated circulating branched-chain amino acids (BCAAs) during insulin resistance are strong predictors of type 2 diabetes mellitus onset. Defects in BCAA degradation are evident in several tissues during insulin resistance and non-alcoholic fatty liver disease (NAFLD). Furthermore, alte...

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Veröffentlicht in:Curr Dev Nutr
Hauptverfasser: Surugihalli, Chaitra, Muralidaran, Vaishna, Patel, Kruti, Gregory, Tabitha, Sunny, Nishanth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Energy and Macronutrient Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8181457/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzab041_044
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