Oral Salmonella msbB Mutant as a Carrier for a Salmonella-Based Vaccine for Prevention and Reversal of Type 1 Diabetes

A therapy that includes an oral vaccine for type 1 diabetes (T1D) using live attenuated Salmonella MvP728 (ΔhtrA/ΔpurD), cytokines (IL10 and TGFβ) and preproinsulin (PPI) antigen in combination with a sub-therapeutic dose of anti-CD3 mAb was developed by our team. The vaccine combination therapy red...

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Vydáno v:Front Immunol
Hlavní autoři: Cobb, Jacob, Rawson, Jeffrey, Gonzalez, Nelson, Hensel, Michael, Kandeel, Fouad, Husseiny, Mohamed I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8181392/
https://ncbi.nlm.nih.gov/pubmed/34108968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.667897
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