Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation

The circadian clock possesses robust systems to maintain the rhythm approximately 24 h, from cellular to organismal levels, whereas aging is known to be one of the risk factors linked to the alternation of circadian physiology and behavior. The amount of many metabolites in the cells/body is altered...

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Bibliografske podrobnosti
izdano v:Front Neurosci
Main Authors: Ashimori, Atsushige, Nakahata, Yasukazu, Sato, Toshiya, Fukamizu, Yuichiro, Matsui, Takaaki, Yoshitane, Hikari, Fukada, Yoshitaka, Shinohara, Kazuyuki, Bessho, Yasumasa
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180908/
https://ncbi.nlm.nih.gov/pubmed/34108855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.647589
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