Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation

The circadian clock possesses robust systems to maintain the rhythm approximately 24 h, from cellular to organismal levels, whereas aging is known to be one of the risk factors linked to the alternation of circadian physiology and behavior. The amount of many metabolites in the cells/body is altered...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Ashimori, Atsushige, Nakahata, Yasukazu, Sato, Toshiya, Fukamizu, Yuichiro, Matsui, Takaaki, Yoshitane, Hikari, Fukada, Yoshitaka, Shinohara, Kazuyuki, Bessho, Yasumasa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180908/
https://ncbi.nlm.nih.gov/pubmed/34108855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.647589
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