Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF

Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation. Multi-stage mechanistic analy...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Development
Asıl Yazarlar: Li, Hao, Kurtzeborn, Kristen, Kupari, Jussi, Gui, Yujuan, Siefker, Edward, Lu, Benson, Mätlik, Kärt, Olfat, Soophie, Montaño-Rodríguez, Ana R., Huh, Sung-Ho, Costantini, Franklin, Andressoo, Jaan-Olle, Kuure, Satu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180252/
https://ncbi.nlm.nih.gov/pubmed/34032268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.197475
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