Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF

Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation. Multi-stage mechanistic analy...

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Bibliographic Details
Published in:Development
Main Authors: Li, Hao, Kurtzeborn, Kristen, Kupari, Jussi, Gui, Yujuan, Siefker, Edward, Lu, Benson, Mätlik, Kärt, Olfat, Soophie, Montaño-Rodríguez, Ana R., Huh, Sung-Ho, Costantini, Franklin, Andressoo, Jaan-Olle, Kuure, Satu
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180252/
https://ncbi.nlm.nih.gov/pubmed/34032268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.197475
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