Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF

Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation. Multi-stage mechanistic analy...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Li, Hao, Kurtzeborn, Kristen, Kupari, Jussi, Gui, Yujuan, Siefker, Edward, Lu, Benson, Mätlik, Kärt, Olfat, Soophie, Montaño-Rodríguez, Ana R., Huh, Sung-Ho, Costantini, Franklin, Andressoo, Jaan-Olle, Kuure, Satu
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180252/
https://ncbi.nlm.nih.gov/pubmed/34032268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.197475
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