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Glycoengineering artificial receptors for microglia to phagocytose Aβ aggregates

Oligomeric and fibrillar amyloid-β (Aβ) are principally internalized via receptor-mediated endocytosis (RME) by microglia, the main scavenger of Aβ in the brain. Nevertheless, the inflammatory cascade will be evoked after vast Aβ aggregate binding to pattern recognition receptors on the cell membran...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Yu, Dongqin, Liu, Chun, Zhang, Haochen, Ren, Jinsong, Qu, Xiaogang
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179537/
https://ncbi.nlm.nih.gov/pubmed/34163743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc07067j
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