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Glycoengineering artificial receptors for microglia to phagocytose Aβ aggregates
Oligomeric and fibrillar amyloid-β (Aβ) are principally internalized via receptor-mediated endocytosis (RME) by microglia, the main scavenger of Aβ in the brain. Nevertheless, the inflammatory cascade will be evoked after vast Aβ aggregate binding to pattern recognition receptors on the cell membran...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179537/ https://ncbi.nlm.nih.gov/pubmed/34163743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc07067j |
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