Directed evolution of cyclic peptides for inhibition of autophagy

In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy in many cancer types. Unfortunately, chloroquine (CQ) and hydroxychloroquine (HCQ), two autophagy inhibitors in clinical trials, suffer from...

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Publicat a:Chem Sci
Autors principals: Gray, Joshua P., Uddin, Md. Nasir, Chaudhari, Rajan, Sutton, Margie N., Yang, Hailing, Rask, Philip, Locke, Hannah, Engel, Brian J., Batistatou, Nefeli, Wang, Jing, Grindel, Brian J., Bhattacharya, Pratip, Gammon, Seth T., Zhang, Shuxing, Piwnica-Worms, David, Kritzer, Joshua A., Lu, Zhen, Bast, Robert C., Millward, Steven W.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society of Chemistry 2021
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179393/
https://ncbi.nlm.nih.gov/pubmed/34163626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03603j
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