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Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes

We report herein the development of a palladium-catalyzed, multicomponent synthesis of indolizines. The reaction proceeds via the carbonylative formation of a high energy, mesoionic pyridine-based 1,3-dipole, which can undergo spontaneous cycloaddition with alkynes. Overall, this provides a route to...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Roy, Sébastien A., Zgheib, José, Zhou, Cuihan, Arndtsen, Bruce A.
Format: Artigo
Langue:Inglês
Publié: The Royal Society of Chemistry 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179343/
https://ncbi.nlm.nih.gov/pubmed/34163991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03977b
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