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Does liquid–liquid phase separation drive peptide folding?

Proline–arginine (PR) dipeptide repeats have been shown to undergo liquid–liquid phase separation and are an example of a growing number of intrinsically disordered proteins that can assemble into membraneless organelles. These structures have been posited as nucleation sites for pathogenic protein...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Edun, Dean N., Flanagan, Meredith R., Serrano, Arnaldo L.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society of Chemistry 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179267/
https://ncbi.nlm.nih.gov/pubmed/34164013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04993j
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