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Small peptide diversification through photoredox-catalyzed oxidative C-terminal modification

A photoredox-catalyzed oxidative decarboxylative coupling of small peptides is reported, giving access to a variety of N,O-acetals. They were used as intermediates for the addition of phenols and indoles, leading to novel peptide scaffolds and bioconjugates. Amino acids with nucleophilic side chains...

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Vydáno v:Chem Sci
Hlavní autoři: Le Du, Eliott, Garreau, Marion, Waser, Jérôme
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179259/
https://ncbi.nlm.nih.gov/pubmed/34164012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc06180h
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