Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma

Fifty percent of diffuse large B cell lymphoma (DLBCL) cases lack cell-surface expression of the class I major histocompatibility complex (MHC-I), thus escaping recognition by cytotoxic T cells. Here we show that, across B cell lymphomas, loss of MHC-I, but not MHC-II, is preferentially restricted t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fangazio, Marco, Ladewig, Erik, Gomez, Karen, Garcia-Ibanez, Laura, Kumar, Rahul, Teruya-Feldstein, Julie, Rossi, Davide, Filip, Ioan, Pan-Hammarström, Qiang, Inghirami, Giorgio, Boldorini, Renzo, Ott, German, Staiger, Annette M., Chapuy, Björn, Gaidano, Gianluca, Bhagat, Govind, Basso, Katia, Rabadan, Raul, Pasqualucci, Laura, Dalla-Favera, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179151/
https://ncbi.nlm.nih.gov/pubmed/34050029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104504118
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