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Ritter-enabled catalytic asymmetric chloroamidation of olefins

Intermolecular asymmetric haloamination reactions are challenging due to the inherently high halenium affinity (HalA) of the nitrogen atom, which often leads to N-halogenated products as a kinetic trap. To circumvent this issue, acetonitrile, possessing a low HalA, was used as the nucleophile in the...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Steigerwald, Daniel C., Soltanzadeh, Bardia, Sarkar, Aritra, Morgenstern, Cecilia C., Staples, Richard J., Borhan, Babak
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179065/
https://ncbi.nlm.nih.gov/pubmed/34163947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05224h
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