Conformational editing of intrinsically disordered protein by α-methylation

Intrinsically disordered proteins (IDPs) constitute a large portion of “Dark Proteome” – difficult to characterize or yet to be discovered protein structures. Here we used conformationally constrained α-methylated amino acids to bias the conformational ensemble in the free unstructured activation do...

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Vydáno v:Chem Sci
Hlavní autoři: Bauer, Valentin, Schmidtgall, Boris, Gógl, Gergő, Dolenc, Jozica, Osz, Judit, Nominé, Yves, Kostmann, Camille, Cousido-Siah, Alexandra, Mitschler, André, Rochel, Natacha, Travé, Gilles, Kieffer, Bruno, Torbeev, Vladimir
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178997/
https://ncbi.nlm.nih.gov/pubmed/34163874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04482b
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