Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase

Protein domains often recognize short linear protein motifs composed of a core conserved consensus sequence surrounded by less critical, modulatory positions. PTEN, a lipid phosphatase involved in phosphatidylinositol 3-kinase (PI3K) pathway, contains such a short motif located at the extreme C-term...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Jané, Pau, Gógl, Gergő, Kostmann, Camille, Bich, Goran, Girault, Virginie, Caillet-Saguy, Célia, Eberling, Pascal, Vincentelli, Renaud, Wolff, Nicolas, Travé, Gilles, Nominé, Yves
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774954/
https://ncbi.nlm.nih.gov/pubmed/33382810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0244613
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