Designed alpha-helical barrels for charge-selective peptide translocation

Synthetic alpha-helix based pores for selective sensing of peptides have not been characterized previously. Here, we report large transmembrane pores, pPorA formed from short synthetic alpha-helical peptides of tunable conductance and selectivity for single-molecule sensing of peptides. We quantifie...

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Veröffentlicht in:Chem Sci
Hauptverfasser: R., Smrithi Krishnan, Puthumadathil, Neethu, Shaji, Amina H., Santhosh Kumar, K., Mohan, Gayathri, Mahendran, Kozhinjampara R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178987/
https://ncbi.nlm.nih.gov/pubmed/34163795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04856a
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