Interaction of 8-anilinonaphthalene-1-sulfonate with SARS-CoV-2 main protease and its application as a fluorescent probe for inhibitor identification

The 3C-like main protease of SARS-CoV-2 (3CL(Pro)) is responsible for the cleavage of the viral polyprotein. This process is essential for the viral life cycle. Therefore, 3CL(Pro) is a promising target to develop antiviral drugs for COVID-19 prevention and treatment. Traditional enzymatic assays fo...

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Vydáno v:Comput Struct Biotechnol J
Hlavní autoři: Deetanya, Peerapon, Hengphasatporn, Kowit, Wilasluck, Patcharin, Shigeta, Yasuteru, Rungrotmongkol, Thanyada, Wangkanont, Kittikhun
Médium: Artigo
Jazyk:Inglês
Vydáno: Research Network of Computational and Structural Biotechnology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178945/
https://ncbi.nlm.nih.gov/pubmed/34109016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.05.053
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