Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice

INTRODUCTION: The effect of 11β-hydroxysteroid dehydrogenase type1 (11β-HSD1) inhibition on hepatic steatosis is incompletely understood. Here, we aimed to determine the therapeutic effect of BVT.2733, a selective 11β-HSD1 inhibitor, on hepatic steatosis. MATERIALS AND METHODS: C57B/6J mice were ran...

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發表在:Drug Des Devel Ther
Main Authors: Li, Huashan, Sheng, Jianying, Wang, Jing, Gao, Haiting, Yu, Jing, Ding, Guoxian, Ding, Ning, He, Weiqi, Zha, Juanmin
格式: Artigo
語言:Inglês
出版: Dove 2021
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178584/
https://ncbi.nlm.nih.gov/pubmed/34103895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S285828
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