WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways

Cholangiocarcinoma (CCA) is a highly aggressive malignancy with extremely poor prognoses. The oncogenic role and prognostic value of c-Myc in CCA is not well elucidated. WD repeat domain 5 (WDR5) is a critical regulatory factor directly interacting with c-Myc to regulate c-Myc recruitment at chromos...

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Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Chen, Tianli, Li, Kangshuai, Liu, Zengli, Liu, Jialiang, Wang, Yue, Sun, Rongqi, Li, Zhipeng, Qiu, Bo, Zhang, Xiaoming, Ren, Guangli, Xu, Yunfei, Zhang, Zongli
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2021
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178527/
https://ncbi.nlm.nih.gov/pubmed/33601056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.017
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