HMGA1-TRIP13 axis promotes stemness and epithelial mesenchymal transition of perihilar cholangiocarcinoma in a positive feedback loop dependent on c-Myc

BACKGROUND: Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of radiotherapy and chemotherapy of pCCA are very l...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Li, Zhipeng, Liu, Jialiang, Chen, Tianli, Sun, Rongqi, Liu, Zengli, Qiu, Bo, Xu, Yunfei, Zhang, Zongli
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923631/
https://ncbi.nlm.nih.gov/pubmed/33648560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01890-1
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