USP22 deficiency in melanoma mediates resistance to T cells through IFNγ-JAK1-STAT1 signal axis

Genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated 9 (Cas9)-mediated loss-of-function screens are powerful tools for identifying genes responsible for diverse phenotypes. Here, we perturbed genes in melanoma cells to screen for genes involved in tumor es...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Li, Min, Xu, Yanqin, Liang, Jie, Lin, Hao, Qi, Xinyue, Li, Fanlin, Han, Ping, Gao, Yanfeng, Yang, Xuanming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178440/
https://ncbi.nlm.nih.gov/pubmed/33601053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.018
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