Autophagy Facilitates IFN-γ-induced Jak2-STAT1 Activation and Cellular Inflammation

Autophagy is regulated for IFN-γ-mediated antimicrobial efficacy; however, its molecular effects for IFN-γ signaling are largely unknown. Here, we show that autophagy facilitates IFN-γ-activated Jak2-STAT1. IFN-γ induces autophagy in wild-type but not in autophagy protein 5 (Atg5(−/−))-deficient mou...

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Detalhes bibliográficos
Main Authors: Chang, Yu-Ping, Tsai, Cheng-Chieh, Huang, Wei-Ching, Wang, Chi-Yun, Chen, Chia-Ling, Lin, Yee-Shin, Kai, Jui-In, Hsieh, Chia-Yuan, Cheng, Yi-Lin, Choi, Pui-Ching, Chen, Shun-Hua, Chang, Shih-Ping, Liu, Hsiao-Sheng, Lin, Chiou-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937899/
https://ncbi.nlm.nih.gov/pubmed/20592027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133355
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