LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson’s disease

The LRRK2 p.G2019S Parkinson’s disease (PD) variant is associated with elevated glucocerebrosidase (GCase) activity in peripheral blood. We aimed to evaluate the association of other LRRK2 variants with PD and its association with GCase activity. LRRK2 and GBA were fully sequenced in 1,123 PD patien...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Sosero, Yuri L., Yu, Eric, Krohn, Lynne, Rudakou, Uladzislau, Mufti, Kheireddin, Ruskey, Jennifer A., Asayesh, Farnaz, Laurent, Sandra B., Spiegelman, Dan, Fahn, Stanley, Waters, Cheryl, Sardi, S. Pablo, Bandres-Ciga, Sara, Alcalay, Roy N., Gan-Or, Ziv, Senkevich, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178224/
https://ncbi.nlm.nih.gov/pubmed/33781610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2021.02.018
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