Common and rare GCH1 variants are associated with Parkinson disease

GCH1 encodes the enzyme GTP cyclohydrolase 1, essential for dopamine synthesis in nigrostriatal cells, and rare mutations in GCH1 may lead to Dopa-responsive dystonia (DRD). While GCH1 is implicated in genome-wide association studies in Parkinson disease (PD), only a few studies examined the role of...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Neurobiol Aging
Auteurs principaux: Rudakou, Uladzislau, Amar Bencheikh, Bouchra Ouled, Ruskey, Jennifer A., Krohn, Lynne, Laurent, Sandra B., Spiegelman, Dan, Liong, Christopher, Fahn, Stanley, Waters, Cheryl, Monchi, Oury, Fon, Edward A., Dauvilliers, Yves, Alcalay, Roy N., Dupré, Nicolas, Gan-Or, Ziv
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251729/
https://ncbi.nlm.nih.gov/pubmed/30314816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.09.008
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires