Salmonella-Mediated Therapy Targeting Indoleamine 2, 3-Dioxygenase 1 (IDO) Activates Innate Immunity and Mitigates Colorectal Cancer Growth

Patients with colon cancer remain largely refractory to current immunotherapeutic strategies. This is, in part, due to the overexpression of the immune checkpoint protein indoleamine 2,3-dioxygenase 1 (IDO). IDO is an important enzyme contributing to tumor-mediated immunosuppression and also correla...

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Dettagli Bibliografici
Pubblicato in:Cancer Gene Ther
Autori principali: Phan, Thuy, Nguyen, Vu H., D’Alincourt, Marcela S, Manuel, Edwin R., Kaltcheva, Teodora, Tsai, Weimin, Blazar, Bruce R., Diamond, Don J., Melstrom, Laleh G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177749/
https://ncbi.nlm.nih.gov/pubmed/30824815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-019-0089-7
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