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RNase L limits host and viral protein synthesis via inhibition of mRNA export
RNase L is widely thought to limit viral protein synthesis by cleaving host rRNA and viral mRNA, resulting in translation arrest and viral mRNA degradation. Here, we show that the mRNAs of dengue virus and influenza A virus largely escape RNase L–mediated mRNA decay, and this permits viral protein p...
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| Veröffentlicht in: | Sci Adv |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8177694/ https://ncbi.nlm.nih.gov/pubmed/34088676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh2479 |
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