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RNase L limits host and viral protein synthesis via inhibition of mRNA export

RNase L is widely thought to limit viral protein synthesis by cleaving host rRNA and viral mRNA, resulting in translation arrest and viral mRNA degradation. Here, we show that the mRNAs of dengue virus and influenza A virus largely escape RNase L–mediated mRNA decay, and this permits viral protein p...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Burke, James M., Gilchrist, Alison R., Sawyer, Sara L., Parker, Roy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177694/
https://ncbi.nlm.nih.gov/pubmed/34088676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh2479
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