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RNase L limits host and viral protein synthesis via inhibition of mRNA export

RNase L is widely thought to limit viral protein synthesis by cleaving host rRNA and viral mRNA, resulting in translation arrest and viral mRNA degradation. Here, we show that the mRNAs of dengue virus and influenza A virus largely escape RNase L–mediated mRNA decay, and this permits viral protein p...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Burke, James M., Gilchrist, Alison R., Sawyer, Sara L., Parker, Roy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177694/
https://ncbi.nlm.nih.gov/pubmed/34088676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh2479
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