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RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits translation initiation through eIF2α phosphorylation, which triggers stress granule (SG) formation and promotes translation of...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754297/ https://ncbi.nlm.nih.gov/pubmed/31494035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.029 |
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