Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection

Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery, nevertheless, have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Further, whether bone marrow derived hematopoietic stem and progenitor cells (HSPCs) can enter the brain...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhang, Jianshui, Lohani, Saroj Chandra, Cheng, Yilun, Wang, Tao, Guo, Lili, Kim, Woong-Ki, Gorantla, Santhi, Li, Qingsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176960/
https://ncbi.nlm.nih.gov/pubmed/34093573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.672415
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