Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

BACKGROUND: Pamamycins are macrodiolides of polyketide origin which form a family of differently large homologues with molecular weights between 579 and 663. They offer promising biological activity against pathogenic fungi and gram-positive bacteria. Admittedly, production titers are very low, and...

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Publicado en:Microb Cell Fact
Autores principales: Gläser, Lars, Kuhl, Martin, Stegmüller, Julian, Rückert, Christian, Myronovskyi, Maksym, Kalinowski, Jörn, Luzhetskyy, Andriy, Wittmann, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176718/
https://ncbi.nlm.nih.gov/pubmed/34082758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01602-6
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