Dexmedetomidine Protects Human Cardiomyocytes Against Ischemia-Reperfusion Injury Through α2-Adrenergic Receptor/AMPK-Dependent Autophagy

Background: Ischemia-reperfusion injury (I/R) strongly affects the prognosis of children with complicated congenital heart diseases (CHDs) who undergo long-term cardiac surgical processes. Recently, the α2-adrenergic receptor agonist Dexmedetomidine (Dex) has been reported to protect cardiomyocytes...

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Publicado en:Front Pharmacol
Autores principales: Xiao, Yingying, Li, Junpeng, Qiu, Lisheng, Jiang, Chuan, Huang, Yanhui, Liu, Jinfen, Sun, Qi, Hong, Haifa, Ye, Lincai
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176440/
https://ncbi.nlm.nih.gov/pubmed/34093174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.615424
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