Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model

Antimicrobial resistance in Neisseria gonorrhoeae is threatening the treatment and control of gonorrhea globally, and new treatment options are imperative. Utilizing our dynamic in vitro hollow fiber infection model (HFIM), we examined the pharmacodynamics of the first-in-class spiropyrimidinetrione...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Alirol, Emilie, Franceschi, Francois, Gustafsson, Tomas N., Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175963/
https://ncbi.nlm.nih.gov/pubmed/34093206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682135
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